The Kurnakov test, also known as Kurnakov’s reaction, is a chemical test that The test was devised by Soviet chemist Nikolai Semenovich Kurnakov. I’m trying to answer this question: However, I don’t fully understand the exact synthesis of the thiourea complexes. For one, I don’t understand. of substituted pyrimidines and their products from thiourea in Kurnakov’s reaction react with thiourea (tu) to give different products (Kurnakov’s test).
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Cisplatincisplatinum or cis -diamminedichloridoplatinum II CDDP is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas e.
It was the first member of its class, which now also includes carboplatin and oxaliplatin. Upon administration, a chloride ligand undergoes slow displacement with water an aqua ligand molecules, in a process termed aquation.
Kurjakov, the platnum cross-links two bases via displacement of the other chloride ligand. Most kugnakov among the DNA changes are the 1,2-intrastrand cross-links with purine bases.
Kurnakov test | Revolvy
Other adducts include inter-strand crosslinks and nonfunctional adducts that have been postulated to contribute to cisplatin’s activity.
Interaction with cellular proteins, particularly HMG domain proteins, has also been advanced as a mechanism of interfering with mitosis, although this is probably not its primary method of action.
Note that although cisplatin is frequently designated as an alkylating agent, it has no alkyl group and cannot carry out alkylating reactions. It is correctly classified as alkylating-like. Transplatin, the trans diastereomer of cisplatin, has formula trans -[PtCl 2 NH 3 2 ] and does not exhibit a comparably useful pharmacological effect.
Its low activity is generally thought to be due to rapid deactivation of the drug before it can arrive at the DNA. In a procedure by Woollins et al.
Peyrone in known as Peyrone’s salt. The bacteria grow to times their normal length but cell division fails.
Rosenberg then conducted a series of experiments to test the effects various platinum coordination complexes on sarcomas artificially implanted in rats. This study found that cis-diamminedichloridoplatinum II was the most effective out of this group, which started the tesy career of cisplatin. Detailed studies on its molecular mechanism of action, using a variety of spectrocopic methods including X-ray, NMR spectroscopy, and twst physico-chemical methods, revealed its ability to form irreversible crosslinks with bases in DNA.
World of Molecules Home Page. Cisplantin Cisplatincisplatinum or cis -diamminedichloridoplatinum II CDDP is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas e. Pharmacology Upon administration, a chloride ligand undergoes slow displacement with water an aqua ligand molecules, in a process termed aquation. Transplatin Transplatin, the trans diastereomer of cisplatin, has formula trans -[PtCl 2 NH 3 2 ] and does not exhibit a comparably useful pharmacological effect.
Nikolai Semenovich Kurnakov
Nephrotoxicity kidney damage is a major concern when cisplatin is given. The dose is reduced when the patient’s creatinine clearance a measure of renal function is reduced. Adequate hydration and diuresis is used to prevent renal damage. The nephrotoxicity of platinum-class drugs seems to be related to reactive oxygen species and in animal models can be ameliorated by free radical scavenging agents. This is a dose-limiting toxicity. Neurotoxicity nerve damage can be anticipated by performing nerve conduction studies before and after treatment.
Cisplatin is one of the most emetogenic chemotherapy agents, but this is managed with prophylactic antiemetics e. Aprepitant combined with ondansetron and dexamethasone has been shown to be better for highly emetogenic chemotherapy than just ondansetron and dexamethasone. Audiometric analysis may be necessary to assess the severity of ototoxicity. Other drugs such as the aminoglycoside antibiotic class may also cause ototoxicity, and the administration of this class of antibiotics in patients receiving cisplatin is generally avoided.
The ototoxicity of both the aminoglycosides and cisplatin may be related to their kurnakvo to bind to melanin in the stria vascularis of the inner ear or the generation of reactive oxygen species. Cisplatin can cause hypomagnesaemia, hypokalaemia and hypocalcaemia. The hypocalcaemia seems to occur in those with low serum magnesium secondary to cisplatin, so it is not primarily due to the Cisplatin. References Stephen Trzaska 20 Jun A high performance liquid chromatographic application of kurnakow’s test”.
Ann Chemie Pharm ; Indian Journal of Chemistryvolume 8, pp. Hall, and Trevor W. Some or all kurnakof this text has been obtained from Wikipedia, the free encyclopedia. Wikipedia is powered by MediaWikian open source wiki engine.